There are 196 volatile (or active) chemical compounds found in the Yerba Mate plant. Of those, 144 are also found in green tea. Yerba Mate contains 11 polyphenols. Polyphenols are a group of phytochemicals. Phytochemicals (phyto- meaning plant) are recently-discovered compounds that act as powerful antioxidants and are considered to exhibit anti-cancer effects in mammals by strengthening an organism's natural defenses and protecting it against cellular destruction (i.e. lycopene in tomatoes, flavonoids in blueberries, and isoflavones in soy). In addition to polyphenols, Yerba Mate leaves contain saponins (In fact, one recent study yielded 3 new saponins in the Yerba Mate leaf!) Saponins are phytochemicals that have been found to specifically stimulate the immune system and aid the body in protecting against disease.

In 2005, researchers at the University of Illinois studied 25 different types of mate. They found the tea to contain "higher levels of antioxidants than green tea"... and, based on cell studies, "may help prevent oral cancer."

Each infusion of Mate contains:
Vitamins: A, C, E, B1, B2, Niacin (B3), B5, B Complex
Minerals: Calcium, Manganese, Iron, Selenium, Potassium, Magnesium, Phosphorus
Additional Compounds: Fatty Acids, Chlorophyll, Flavonols, Polyphenols, Trace Minerals, Antioxidants, Pantothenic Acid and 15 Amino Acids.

According to Dr. Mowrey, Director of Mountainwest Institute of Herbal Sciences, one group of investigators from the Pasteur Institute and the Paris Scientific Society concluded that Yerba Mate contains "practically all of the vitamins necessary to sustain life." They focused especially on Pantothenic Acid, remarking that it is "rare to find a plant with so much of this significant and vital nutrient. . . It is indeed difficult to find a plant in any area of the world equal to Mate in nutritional value."

In addition, results from a study done by researchers at the University of Madrid assert a high content of mineral elements, especially K, Mg, and Mn, in Mate. They considered those findings "to be of great relevance" to the nutritional value of Mate infusions.

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